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The nature of the question here is not exactly clear. Hopefully the following details will provide you with the information which you are seeking, or will at least allow for further clarification.
When agentlessly scanning a machine, the console machine will need to be able to successfully resolve the target machine via DNS. The console machine will then attempt to read the registry and file structure of the target machine.
When using an agent, it is necessary that the agent is able to successfully resolve the console machine via DNS. The agent machine will then attempt to authenticate a connection to the console machine via TCP3121.
A 'Distribution Server' is simply a network share to which machines are directed to obtain data and patch files. The 'Distribution Server' must be resolvable via DNS, and must be accessible by the machines which are directed to it.
For more specific details outlining the configuration and port requirements, please also review the following topics within our administration guide (also available via the 'Help>Index' menu):