The current versions of Protect are not compatible with Windows 10. You can see a list of compatible OS's in this guide: http://rs.shavlik.com/documents/Shavlik_Protect_92/rn-prt-9-2.pdf
You will retain 99% on your settings as long as you have you Protect database.
FYI - Uninstall/reinstall of Protect on the Win 10 system solved my issue. I've been able to patch and deploy clients successfully. However there is an issue with detection logic. Protect on Windows 10 shows clients as missing three IE 11 updates: MS14-012, MS14-018, and MS16-001. However, scanning the same clients from Protect running on a Windows 7 system doesn't show these as missing. Weird.
It is weird, but it's not something we can look into until the configuration is supported.