I run across SCCM 2012 r2 installations where they use SCCM "add-ins" such as 1E Nomad or Adaptiva OneSite. At a high-level, both of these products are used to reduce SCCM infrastructure by leveraging end-user devices as distribution points.
Does Shavlik Patch work when these types of products have been implemented?
We've haven't performed any compatibility testing between Shavlik Patch and those products. That being said, Shavlik Patch and those other products should be compatible since we don't do anything on the endpoint to download patches. All of that is handled by the Configuration Manager so you should get the same benefit.