You are unable to publish updates using Shavlik Patch.
This error has been shown in C:\Users\*SCCM-Admin*\Shavlik\Shavlik Patch\AutoPublish.log
PublishItem: InvalidException occurred during publishing: Failed to sign package; error was: 2148081670
2148081670 is a Microsoft error that refers to certificate issues. There could be many causes to this error including mismatched certificates leftover from a previously SCUP (System Center Updates Publisher) configuration.
Verify the certificate in the Shavlik Patch Settings and the certificates in the Trusted Publishers and Trusted Root Certificate Authorities certificate store are the same on your WSUS.